Natural Herb Library

All-Grass of Entire Meconopsis

Chinese
全缘叶绿绒蒿
Pinyin
Quan Yuan Ye Lv Rong Hao
Latin
Herba Meconopsidis Integrifoliae
Botanical illustration of All-Grass of Entire Meconopsis, Meconopsis integrifolia, showing habit, leaves, flowers, capsule, seed, root, and diagnostic plant details.
Botanical plate by Kodi . View print →

Known in TCM as Quan Yuan Ye Lv Rong Hao (全缘叶绿绒蒿), this bitter, cold herb enters the Lung and Liver. Traditionally, it clears heat and resolves toxin; primary Tibetan medicine treatment for pneumonia, hepatitis, and febrile infectious conditions, most often applied for hepatitis, pneumonia, and nafld. Modern research has identified Quercetin among its active constituents.

Part used: Whole herb

Also Known As

Meconopsidis

Latin: Herba Meconopsidis Integrifoliae | Pinyin: Quan Yuan Ye Lv Rong Hao | Chinese: 全缘叶绿绒蒿

TCM Properties

Taste
bitter
Temperature
cold
Channels
Lung, Liver

Traditional Use

Primary Actions

  • Clears heat and resolves toxin; primary Tibetan medicine treatment for pneumonia, hepatitis, and febrile infectious conditions
  • Reduces inflammation and alleviates pain; used for headaches, edema, and inflammatory swelling
  • Supports Liver and cools blood; hepatoprotective application in liver heat and toxic patterns

Secondary Actions

  • Clears Lung heat and stops cough; treats heat-type respiratory conditions with thick yellow phlegm
  • Modern adjunct for NAFLD … improves hepatic lipid metabolism and reduces hepatic steatosis
  • Potential anticancer application … induces apoptosis in leukaemia cell lines via mitochondrial pathway

Classic Formulas

  • Shi Wei Gan Ning San (十味甘宁散) … Tibetan formula of ten herbs for chronic liver fibrosis and hepatitis; M. integrifolia is one of seven principal herbs

Classical References

  • Traditional Tibetan materia medica … honoured as one of the 'Four Divine Herbs' (bzhi thang) for its profound heat-clearing and detoxifying properties; Tibetan name: ga bu lcan sog
  • Qinghai-Tibet Plateau ethnomedicinal tradition … collected from high-altitude alpine meadows (3,000–5,000 m) and used fresh or dried for treating liver disease and pneumonia

Modern Research

Active Compounds

  • Quercetin
  • Luteolin
  • Flavonol diglucosides (quercetin-3-O-glucosyl-glucoside series, four isolated compounds)
  • Alkaloids (29 identified compounds in genus)
  • Glycerophospholipids (48 identified compounds in genus)
  • Arachidonic acid
  • Linoleic acid
  • Gamma-linolenic acid

Studied Effects

  • Hepatoprotective … ethanolic extract significantly reduces ALT/AST in CCl4-induced liver injury models; restores antioxidant enzyme levels (PMID 23707208)
  • Anti-NAFLD … ethyl acetate fraction reduces hepatic TG and LDL, inhibits lipid droplet deposition in HepG2 cells via AMPK/SREPB-1c/PPAR-α pathway (PMID 39795910)
  • Anti-inflammatory … dose-dependent suppression of IL-1A, IL-1B, IL-6, and TNF; nitric oxide inhibition superior to blue-flowered Meconopsis (PMC11509530)
  • Antioxidant … elevates glutathione, restores superoxide dismutase activity in oxidative stress models
  • Anticancer … induces mitochondria-mediated apoptosis and G2/M cell cycle arrest in K562 leukaemia cells with low toxicity to normal cells (PMID 26133762)

PubMed References

Safety & Interactions

Contraindications

  • Cold or deficiency-cold patterns (Spleen-Stomach cold, yang deficiency) … cold thermal nature may aggravate deficiency conditions
  • Hypersensitivity to Papaveraceae family … although non-psychoactive, cross-reactivity within the family is possible

Cautions

  • No clinically documented drug interactions identified at time of review; monitoring advised when combined with hepatic drugs given liver-active constituents
  • Alkaloid content warrants caution with prolonged high-dose use; standard decoction quantities are considered safe in traditional practice
  • High-altitude endemic herb … verify sourcing and species identification, as Meconopsis genus contains multiple species with different alkaloid profiles

Conditions

Frequently Asked Questions

What is All-Grass of Entire Meconopsis used for?

All-Grass of Entire Meconopsis is traditionally used to Clears heat and resolves toxin; primary Tibetan medicine treatment for pneumonia, hepatitis, and febrile infectious conditions, Reduces inflammation and alleviates pain; used for headaches, edema, and inflammatory swelling, Supports Liver and cools blood; hepatoprotective application in liver heat and toxic patterns. Research has investigated its effects on: Hepatoprotective … ethanolic extract significantly reduces ALT/AST in CCl4-induced liver injury models; restores antioxidant enzyme levels (PMID 23707208); Anti-NAFLD … ethyl acetate fraction reduces hepatic TG and LDL, inhibits lipid droplet deposition in HepG2 cells via AMPK/SREPB-1c/PPAR-α pathway (PMID 39795910).

What are other names for All-Grass of Entire Meconopsis?

All-Grass of Entire Meconopsis is also known as Meconopsidis. In TCM: 全缘叶绿绒蒿 (Quan Yuan Ye Lv Rong Hao); Herba Meconopsidis Integrifoliae.

Is All-Grass of Entire Meconopsis safe during pregnancy?

The safety of All-Grass of Entire Meconopsis during pregnancy has not been established. Consult a qualified healthcare provider before use.

What are the contraindications for All-Grass of Entire Meconopsis?

All-Grass of Entire Meconopsis should not be used in: Cold or deficiency-cold patterns (Spleen-Stomach cold, yang deficiency) … cold thermal nature may aggravate deficiency conditions; Hypersensitivity to Papaveraceae family … although non-psychoactive, cross-reactivity within the family is possible. Consult a qualified practitioner before use.