Bile Arisaema
- Chinese
- 胆南星
- Pinyin
- Dan Nan Xing
- Latin
- Rhizoma Arisaema Cum Bile
Known in TCM as Dan Nan Xing (胆南星), this bitter and acrid, cool herb enters the Lung, Liver, and Spleen. Traditionally, it clears Heat and transforms phlegm-heat - used for thick yellow sputum, heat-agitated phlegm in the Lung, and turbid phlegm obstructing the sensory orifices, most often applied for epilepsy, stroke, and productive cough. Modern research has identified Cholic among its active constituents.
Part used: Rhizome
Also Known As
Latin: Rhizoma Arisaema Cum Bile | Pinyin: Dan Nan Xing | Chinese: 胆南星
TCM Properties
- Taste
- bitter, acrid
- Temperature
- cool
- Channels
- Lung, Liver, Spleen
Traditional Use
Primary Actions
- Clears Heat and transforms phlegm-heat - used for thick yellow sputum, heat-agitated phlegm in the Lung, and turbid phlegm obstructing the sensory orifices.
- Extinguishes wind and calms convulsions - applied when phlegm-heat stirs internal wind, causing seizures, childhood convulsions, trembling, or fright-type agitation.
- Addresses stroke and epilepsy with phlegm obstruction - a classic choice when copious sputum, loss of consciousness, or recurrent convulsive disorders show a clear phlegm-heat component.
- Represents the cooling transformation of Tian Nan Xing - bile processing redirects the warm, drying, toxic raw Arisaema toward a cooler heat-phlegm and convulsion role.
Secondary Actions
- Dan Nan Xing is a processed specialty medicinal rather than a casual substitute for raw Tian Nan Xing; the bile fermentation changes both temperature and clinical emphasis.
- It is especially suited to phlegm-heat wind presentations, whereas unprocessed or ginger-alum processed Tian Nan Xing is more often used for cold-damp or stubborn wind-phlegm.
Classic Formulas
- Niu Huang Bao Long Wan (牛黄抱龙丸) - pediatric convulsion pill in which Dan Nan Xing helps clear heat, resolve phlegm, and relieve convulsions in heat-phlegm closure states.
- Qi Zhen Dan (七珍丹) - classical pediatric convulsion formula that includes Dan Nan Xing to cool phlegm and settle fright when thick phlegm and heat disturb the spirit.
Classical References
- TCM Wiki lists Dan Nan Xing with the alternate name Dan Xing and gives the core actions of clearing and resolving heat-phlegm, extinguishing wind, and calming fright.
- Me and Qi and TCM-ADIP both emphasize that this is the bile-processed form of Tian Nan Xing, shifting the herb from warm-toxic phlegm dispersion toward cool heat-phlegm transformation.
- IMPORT NOTE: The spreadsheet split Dan Nan Xing and Dan Xing into separate slugs, but they are the same processed medicinal under full and abbreviated names.
Modern Research
Active Compounds
- Cholic acid and related primary bile acids (bile acids) - major processing-derived constituents introduced by bile fermentation
- Chenodeoxycholic and deoxycholic acid derivatives (bile acids) - part of the transformed bile-acid matrix analyzed in modern processing studies
- Taurocholic and glycocholic acid derivatives (conjugated bile acids) - important markers for quality control of the fermented product
- Residual Arisaema lectins and polysaccharides (plant macromolecules) - part of the underlying rhizome chemistry that remains after processing
- Fermentation-modified small molecules (processing metabolites) - reflect the chemical shift created by bile processing and help distinguish Dan Nan Xing from raw Tian Nan Xing
Studied Effects
- Processing-mechanism work - UPLC-MS profiling of twelve bile acids helped clarify how fermentation changes the chemistry of bile arisaema and linked the product to anti-inflammatory activity in LPS-stimulated THP-1 cells (PMID 31662947)
- Cool-property validation - metabolism research in rat cold/heat models found Arisaema Cum Bile reduced energy-metabolism markers and lowered anal temperature, supporting the pharmacopoeial shift from warm Tian Nan Xing to cool Dan Nan Xing (PMID 36164875)
- Antipyretic and anti-inflammatory activity - ethanol extracts of bile-fermented Arisaema reduced fever and lowered IL-1β, IL-6, TNF-α, PGE2, and cAMP in rats (PMID 40350870)
- Lipid-metabolism effects - a 2025 rat lipidomics study suggested Dan Nan Xing improved hyperlipidemia through PPAR-pathway activation and broader regulation of cholesterol and glycerophospholipid metabolism (PMID 41508208)
PubMed References
- Simultaneous Analysis of Twelve Bile Acids by UPLC-MS and Exploration of the Processing Mechanism of Bile Arisaema by Fermentation. (2019)
- [Study on drug properties of Arisaematis Rhizoma and Arisaema Cum Bile based on substance and energy metabolism in normal and cold/heat syndrome model rats]. (2022)
- [Antipyretic effects of ethanol extracts of Arisaematis Rhizoma fermented with bile from different sources]. (2025)
- [Mechanism of Arisaema Cum Bile in treating hyperlipidemia in rats based on lipidomics]. (2025)
Safety & Interactions
Contraindications
- Dry cough without phlegm or yin-deficiency heat without true phlegm obstruction
- Wind syndromes not driven by phlegm-heat
- Improper substitution with unprocessed Tian Nan Xing
Cautions
- This herb should only be used in its properly bile-processed form; confusing it with raw Tian Nan Xing can substantially change both toxicity and clinical action
- Because it is a specialized processed Arisaema product, it is usually reserved for clear phlegm-heat, convulsion, or closure presentations rather than routine cough use
- MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database
Conditions
Frequently Asked Questions
What is Bile Arisaema used for?
Bile Arisaema is traditionally used to Clears Heat and transforms phlegm-heat - used for thick yellow sputum, heat-agitated phlegm in the Lung, and turbid phlegm obstructing the sensory orifices., Extinguishes wind and calms convulsions - applied when phlegm-heat stirs internal wind, causing seizures, childhood convulsions, trembling, or fright-type agitation., Addresses stroke and epilepsy with phlegm obstruction - a classic choice when copious sputum, loss of consciousness, or recurrent convulsive disorders show a clear phlegm-heat component., Represents the cooling transformation of Tian Nan Xing - bile processing redirects the warm, drying, toxic raw Arisaema toward a cooler heat-phlegm and convulsion role.. Research has investigated its effects on: Processing-mechanism work - UPLC-MS profiling of twelve bile acids helped clarify how fermentation changes the chemistry of bile arisaema and linked the product to anti-inflammatory activity in LPS-stimulated THP-1 cells (PMID 31662947); Cool-property validation - metabolism research in rat cold/heat models found Arisaema Cum Bile reduced energy-metabolism markers and lowered anal temperature, supporting the pharmacopoeial shift from warm Tian Nan Xing to cool Dan Nan Xing (PMID 36164875).
What are other names for Bile Arisaema?
Bile Arisaema is also known as Arisaema. In TCM: 胆南星 (Dan Nan Xing); Rhizoma Arisaema Cum Bile.
Is Bile Arisaema safe during pregnancy?
The safety of Bile Arisaema during pregnancy has not been established. Consult a qualified healthcare provider before use.
What are the contraindications for Bile Arisaema?
Bile Arisaema should not be used in: Dry cough without phlegm or yin-deficiency heat without true phlegm obstruction; Wind syndromes not driven by phlegm-heat; Improper substitution with unprocessed Tian Nan Xing. Consult a qualified practitioner before use.