Catclaw Buttercup Root

Chinese
猫爪草
Pinyin
Mao Zhua Cao
Latin
Radix Ranunculi Ternati
Botanical illustration of Catclaw Buttercup Root, Ranunculus ternatus, showing flowering habit, trifoliate leaves, white flowers, clustered spindle tubers, and diagnostic plant details.
Botanical plate by Kodi .

Known in TCM as Mao Zhua Cao (猫爪草), this sweet and acrid, warm herb enters the Liver and Lung. Traditionally, it transforms Phlegm and dissipates nodules - Mao Zhua Cao is best known for softening and dispersing chronic Phlegm-type lumps such as scrofula, swollen lymph nodes, breast lumps, and thyroid nodules, especially in the neck and upper-body pathways of the Liver and Lung channels, most often applied for thyroid nodule, scrofula, and abscess. Modern research has identified Total among its active constituents.

Part used: Root

Also Known As

Ranunculi

Latin: Radix Ranunculi Ternati | Pinyin: Mao Zhua Cao | Chinese: 猫爪草

TCM Properties

Taste
sweet, acrid
Temperature
warm
Channels
Liver, Lung

Traditional Use

Primary Actions

  • Transforms Phlegm and dissipates nodules - Mao Zhua Cao is best known for softening and dispersing chronic Phlegm-type lumps such as scrofula, swollen lymph nodes, breast lumps, and thyroid nodules, especially in the neck and upper-body pathways of the Liver and Lung channels.
  • Resolves toxicity and reduces swelling - it is traditionally used for abscesses, boils, and toxic swellings when constrained Phlegm and toxin combine into painful localized masses.
  • Disperses accumulations and chronic concretions - beyond superficial swellings, it is applied to deeper longstanding masses and tumor-like lesions in folk and regional oncology-oriented practice, usually as part of a larger phlegm-resolving and toxin-clearing strategy.
  • Supports treatment of scrofula and tuberculosis-type nodular disease - older regional usage emphasizes its role when hard neck lumps, chronic glandular swelling, and lingering toxic-phlegm obstruction are the dominant presentation.

Secondary Actions

  • Mao Zhua Cao is a comparatively late-entering Chinese medicinal rather than one of the great early classics, but it became important in regional practice because of its strong affinity for stubborn nodules.
  • The herb's name comes from its clustered spindle-shaped tubers, which resemble a cat's paw; this distinctive morphology is also important for correct identification and avoiding substitution with related Ranunculus species.

Classic Formulas

  • Mao Zhua Cao with Xia Ku Cao (猫爪草配夏枯草) - classic modern pairing for thyroid nodules, scrofula, and hot-phlegm masses, combining warm phlegm-dissolving movement with cold softening of hardness.
  • Mao Zhua Cao with Jiang Can (猫爪草配僵蚕) - nodular-mass pairing that strengthens Phlegm transformation and collateral penetration for chronic neck lumps and glandular swellings.
  • High-dose single-herb Mao Zhua Cao decoction with rice wine - regional clinical protocol used historically for scrofula and chronic cervical nodules under close supervision.

Classical References

  • Me and Qi describes Mao Zhao Cao / Mao Zhua Cao as warm, sweet, and acrid, entering the Liver and Lung channels and chiefly transforming Phlegm, dissipating nodules, resolving toxicity, and reducing swelling.
  • The herb does not appear as a major named entry in the oldest materia medica canons; later regional handbooks instead emphasize its practical use for neck scrofula and nodular disease.
  • IDENTITY NOTE: the pinyin appears as both Mao Zhua Cao and Mao Zhao Cao in modern sources; this record keeps the more literal claw-based reading while preserving the same herb identity.

Modern Research

Active Compounds

  • Total saponins (triterpenoid saponin fraction) - one of the major bioactive clusters studied for antitumor and inflammatory signaling effects
  • Alkaloid fractions - increasingly studied for anti-metastatic and cell-signaling activity in modern oncology models
  • Water-soluble polysaccharides - traditional tonic-detoxifying fractions explored for immune and antiproliferative effects
  • Flavonoid-type phenolics - supportive antioxidant and signaling-modulating constituents reported in broader Ranunculus research
  • Trace anemonin/protoanemonin-related irritant chemistry - relevant to the slight-toxicity and skin-irritation cautions associated with fresh buttercup-family material

Studied Effects

  • Total saponins of Ranunculus ternatus showed anti-breast-cancer effects in vivo and in vitro, with reported influence on JAK2/STAT3 signaling, inflammatory mediators, tumor growth, and apoptosis pathways (PMID 40351419).
  • A 2024 study reported that alkaloids from Ranunculus ternatus attenuated colorectal-cancer metastasis through epithelial-mesenchymal-transition suppression, supporting the herb's long nodular-mass association in a modern mechanistic frame (PMID 40541119).
  • Ranunculus ternatus extract attenuated renal fibrosis in diabetic nephropathy models via SMYD2-related signaling, showing that research interest now extends beyond oncology into fibrosis and inflammatory remodeling (PMID 35142600).

PubMed References

Safety & Interactions

Contraindications

  • Known buttercup-family hypersensitivity
  • Fresh-plant use on fragile or highly reactive skin
  • Unsupervised use for unexplained enlarging masses

Cautions

  • Modern materia medica sources often classify Mao Zhua Cao as slightly toxic, largely because fresh Ranunculus-family material can irritate the skin and mucosa
  • Possible adverse effects from overuse include gastrointestinal irritation, dizziness, dry mouth, and contact blistering from fresh or improperly handled material
  • MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database

Conditions

Frequently Asked Questions

What is Catclaw Buttercup Root used for?

Catclaw Buttercup Root is traditionally used to Transforms Phlegm and dissipates nodules - Mao Zhua Cao is best known for softening and dispersing chronic Phlegm-type lumps such as scrofula, swollen lymph nodes, breast lumps, and thyroid nodules, especially in the neck and upper-body pathways of the Liver and Lung channels., Resolves toxicity and reduces swelling - it is traditionally used for abscesses, boils, and toxic swellings when constrained Phlegm and toxin combine into painful localized masses., Disperses accumulations and chronic concretions - beyond superficial swellings, it is applied to deeper longstanding masses and tumor-like lesions in folk and regional oncology-oriented practice, usually as part of a larger phlegm-resolving and toxin-clearing strategy., Supports treatment of scrofula and tuberculosis-type nodular disease - older regional usage emphasizes its role when hard neck lumps, chronic glandular swelling, and lingering toxic-phlegm obstruction are the dominant presentation.. Research has investigated its effects on: Total saponins of Ranunculus ternatus showed anti-breast-cancer effects in vivo and in vitro, with reported influence on JAK2/STAT3 signaling, inflammatory mediators, tumor growth, and apoptosis pathways (PMID 40351419).; A 2024 study reported that alkaloids from Ranunculus ternatus attenuated colorectal-cancer metastasis through epithelial-mesenchymal-transition suppression, supporting the herb's long nodular-mass association in a modern mechanistic frame (PMID 40541119)..

What are other names for Catclaw Buttercup Root?

Catclaw Buttercup Root is also known as Ranunculi. In TCM: 猫爪草 (Mao Zhua Cao); Radix Ranunculi Ternati.

Is Catclaw Buttercup Root safe during pregnancy?

The safety of Catclaw Buttercup Root during pregnancy has not been established. Consult a qualified healthcare provider before use.

What are the contraindications for Catclaw Buttercup Root?

Catclaw Buttercup Root should not be used in: Known buttercup-family hypersensitivity; Fresh-plant use on fragile or highly reactive skin; Unsupervised use for unexplained enlarging masses. Consult a qualified practitioner before use.