Corydalis Tuber

Chinese
延胡索
Pinyin
Yan Hu Suo
Latin
Rhizoma Corydalis
Botanical illustration of Corydalis Tuber, Corydalis yanhusuo, showing habit, leaves, flowers, tubers, dried material, and diagnostic plant details.
Botanical plate by Kodi .

Known in TCM as Yan Hu Suo (延胡索), this acrid and bitter, warm herb enters the Heart, Liver, and Spleen. Traditionally, it invigorates Blood, moves Qi, and relieves pain - Yan Hu Suo is one of the signature pain herbs of Chinese medicine because it treats both Qi stagnation and Blood stasis, especially when fixed pain and distension coexist, most often applied for abdominal pain, dysmenorrhea, and chest pain. Modern research has identified Tetrahydropalmatine among its active constituents.

Part used: Rhizome

Also Known As

Corydalis

Latin: Rhizoma Corydalis | Pinyin: Yan Hu Suo | Chinese: 延胡索

TCM Properties

Taste
acrid, bitter
Temperature
warm
Channels
Heart, Liver, Spleen

Traditional Use

Primary Actions

  • Invigorates Blood, moves Qi, and relieves pain - Yan Hu Suo is one of the signature pain herbs of Chinese medicine because it treats both Qi stagnation and Blood stasis, especially when fixed pain and distension coexist.
  • Relieves chest, flank, epigastric, and abdominal pain - it is widely used for digestive, menstrual, and constrained Liver-type pain patterns rather than for simple deficiency aches.
  • Addresses traumatic and gynecologic pain - classical use extends to dysmenorrhea, postpartum abdominal pain, traumatic injury, and painful obstruction when movement of stagnation is required.

Secondary Actions

  • Vinegar-processing is a major traditional refinement for Yan Hu Suo because it is thought to direct the herb more strongly toward the Blood level and pain-relieving function.
  • The herb is not merely warming; its importance lies in the unusual combination of moving both Qi and Blood in one medicine.

Classic Formulas

  • Jin Ling Zi San - classic pairing with Chuan Lian Zi for hypochondriac, epigastric, and lower-abdominal pain from constrained Liver Qi with heat or stasis.
  • Yan Hu Suo Zhi Tong Wan - patent-style pain formula built around corydalis for generalized stagnation pain patterns.
  • Shao Fu Zhu Yu Tang - gynecologic stasis formula where Yan Hu Suo assists movement and pain relief in the lower abdomen.
  • Shi Xiao San modifications - used in menstrual and traumatic pain presentations where Blood stasis is acute and painful.

Classical References

  • Materia medica tradition consistently treats Yan Hu Suo as a premier analgesic herb that moves both Qi and Blood, making it unusually versatile across chest, abdominal, and gynecologic pain.
  • Older clinicians often emphasized vinegar-processed Yan Hu Suo for stronger pain relief, a pattern that modern processing research still examines today.
  • Its warm, acrid, bitter profile explains why it is directed at obstructive pain rather than at pain from simple empty deficiency.

Modern Research

Active Compounds

  • Tetrahydropalmatine - the best known alkaloid associated with analgesic and sedative effects
  • Dehydrocorybulbine - a pain-related alkaloid studied in neuropathic and inflammatory models
  • Protopine and related isoquinoline alkaloids - supportive constituents within the broader corydalis alkaloid profile
  • Quaternary and tertiary alkaloid fractions - the main pharmacologically active chemical families in Yan Hu Suo

Studied Effects

  • A 2021 review summarized the analgesic chemistry of Corydalis yanhusuo and highlighted its rich alkaloid profile as the basis for the herb's enduring reputation as a pain medicine (PMID 34946576).
  • Experimental work showed that Corydalis yanhusuo extract has significant antinociceptive activity across inflammatory and neuropathic pain models, supporting its broad traditional use for painful stagnation (PMID 27622550).
  • A 2022 review of processing, compatibility, pharmacology, pharmacokinetics, and safety underscored that vinegar-processing changes efficacy and toxicity considerations and remains central to modern understanding of Yan Hu Suo (PMID 35003289).

PubMed References

Safety & Interactions

Contraindications

  • Pregnancy
  • Heavy menstrual bleeding without stasis
  • Severe Qi or Blood deficiency pain without obstruction

Cautions

  • Yan Hu Suo is a moving pain herb and can be too dispersing when there is active bleeding or clear deficiency without stasis.
  • Its alkaloids may cause dizziness, sedation, or gastrointestinal upset in sensitive patients or excessive doses.
  • Recent literature also raises concern about potential idiosyncratic hepatotoxicity, so prolonged unsupervised use is not ideal.
  • MSK page not found - drug interaction data not available from Memorial Sloan Kettering integrative medicine database

Conditions

Frequently Asked Questions

What is Corydalis Tuber used for?

Corydalis Tuber is traditionally used to Invigorates Blood, moves Qi, and relieves pain - Yan Hu Suo is one of the signature pain herbs of Chinese medicine because it treats both Qi stagnation and Blood stasis, especially when fixed pain and distension coexist., Relieves chest, flank, epigastric, and abdominal pain - it is widely used for digestive, menstrual, and constrained Liver-type pain patterns rather than for simple deficiency aches., Addresses traumatic and gynecologic pain - classical use extends to dysmenorrhea, postpartum abdominal pain, traumatic injury, and painful obstruction when movement of stagnation is required.. Research has investigated its effects on: A 2021 review summarized the analgesic chemistry of Corydalis yanhusuo and highlighted its rich alkaloid profile as the basis for the herb's enduring reputation as a pain medicine (PMID 34946576).; Experimental work showed that Corydalis yanhusuo extract has significant antinociceptive activity across inflammatory and neuropathic pain models, supporting its broad traditional use for painful stagnation (PMID 27622550)..

What are other names for Corydalis Tuber?

Corydalis Tuber is also known as Corydalis. In TCM: 延胡索 (Yan Hu Suo); Rhizoma Corydalis.

Is Corydalis Tuber safe during pregnancy?

Corydalis Tuber is not recommended during pregnancy.

What are the contraindications for Corydalis Tuber?

Corydalis Tuber should not be used in: Pregnancy; Heavy menstrual bleeding without stasis; Severe Qi or Blood deficiency pain without obstruction. Consult a qualified practitioner before use.