Donkey Hide Gelatin
- Chinese
- 阿胶
- Pinyin
- E Jiao
- Latin
- Colla Corii Asini
Known in TCM as E Jiao (阿胶), this sweet, neutral herb enters the Lung, Liver, Kidney, and Heart. Traditionally, it tonifies blood and enriches deficiency - E Jiao is a major blood tonic used for pallor, dizziness, palpitations, and chronic weakness when blood depletion is central, most often applied for anemia, uterine bleeding, and dry cough. Modern research has identified Collagen among its active constituents.
Part used: Gelatin
Also Known As
Latin: Colla Corii Asini | Pinyin: E Jiao | Chinese: 阿胶
TCM Properties
- Taste
- sweet
- Temperature
- neutral
- Channels
- Lung, Liver, Kidney, Heart
Traditional Use
Primary Actions
- Tonifies blood and enriches deficiency - E Jiao is a major blood tonic used for pallor, dizziness, palpitations, and chronic weakness when blood depletion is central.
- Stops bleeding while also nourishing - it is classically used for uterine bleeding, spotting, hemoptysis, and other bleeding patterns where deficiency and dryness are involved rather than blazing excess heat alone.
- Nourishes Yin and moistens the Lung - traditional use extends to dry cough, dry throat, irritative cough, and blood-streaked sputum from dryness or deficiency heat.
- Calms irritability from deficiency - by enriching blood and Yin, E Jiao is also used when restlessness or insomnia reflects depletion rather than excess obstruction.
Secondary Actions
- Because E Jiao is rich and cloying, it is often dissolved into strained decoctions near the end rather than boiled hard with the rest of the herbs.
- High-quality sourcing and authentication matter greatly because commercial E Jiao quality varies and counterfeit or adulterated products are a long-standing concern.
Classic Formulas
- Jiao Ai Tang - classic formula for uterine bleeding and threatened fetal instability in which E Jiao nourishes blood while helping stop bleeding.
- Huang Lian E Jiao Tang - from Shang Han Lun, using E Jiao to nourish Yin and blood while clearing Heart-Kidney irritability with insomnia and restlessness.
- Qing Zao Jiu Fei Tang - includes E Jiao to moisten the Lung and relieve dry cough from autumn dryness or chronic fluid damage.
Classical References
- Traditional materia medica consistently class E Jiao as sweet and neutral, entering the Lung, Liver, and Kidney to tonify blood, stop bleeding, nourish Yin, and moisten dryness.
- Its dual role of stopping bleeding without strongly drying and enriching blood without being sharply moving explains why E Jiao is so prominent in gynecologic and deficiency-dryness formulas.
Modern Research
Active Compounds
- Collagen and gelatin proteins - the dominant structural basis of E Jiao
- Collagen-derived peptides - low-molecular-weight fractions increasingly studied for bioactivity and quality control
- Amino acids - nutritive and analytical constituents used in product characterization
- Species-specific marker peptides - important for authentication of true donkey-hide gelatin products
Studied Effects
- A randomized controlled trial reported that Ejiao improved blood-deficient symptom scores and reduced declines in blood indices among women with blood-deficient symptoms, supporting continued clinical interest in the classic blood-tonic category (PMID 34707496).
- Collagen-derived peptides isolated from Colla Corii Asini showed hematopoietic activity in experimental work, offering a plausible biochemical bridge for its traditional blood-nourishing reputation (PMID 26911525).
- Proteomic and marker-peptide research continues to focus heavily on authentication and quality control, reflecting the commercial importance and adulteration risk of E Jiao products (PMID 28670118).
PubMed References
- Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial (2021)
- Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini (2016)
- Species-specific identification of collagen components in Colla corii asini using a LC-MS/MS method (2017)
Safety & Interactions
Contraindications
- Spleen or Stomach weakness with poor appetite, bloating, or loose stools
- Thick phlegm or damp obstruction without underlying deficiency
Cautions
- E Jiao is rich and can be difficult to digest if used inappropriately or in large amounts.
- Commercial authenticity and source transparency matter because adulteration is a well-known concern.
- Even though E Jiao appears in pregnancy-related classical formulas, that does not make unsupervised pregnancy use broadly appropriate.
Conditions
Frequently Asked Questions
What is Donkey Hide Gelatin used for?
Donkey Hide Gelatin is traditionally used to Tonifies blood and enriches deficiency - E Jiao is a major blood tonic used for pallor, dizziness, palpitations, and chronic weakness when blood depletion is central., Stops bleeding while also nourishing - it is classically used for uterine bleeding, spotting, hemoptysis, and other bleeding patterns where deficiency and dryness are involved rather than blazing excess heat alone., Nourishes Yin and moistens the Lung - traditional use extends to dry cough, dry throat, irritative cough, and blood-streaked sputum from dryness or deficiency heat., Calms irritability from deficiency - by enriching blood and Yin, E Jiao is also used when restlessness or insomnia reflects depletion rather than excess obstruction.. Research has investigated its effects on: A randomized controlled trial reported that Ejiao improved blood-deficient symptom scores and reduced declines in blood indices among women with blood-deficient symptoms, supporting continued clinical interest in the classic blood-tonic category (PMID 34707496).; Collagen-derived peptides isolated from Colla Corii Asini showed hematopoietic activity in experimental work, offering a plausible biochemical bridge for its traditional blood-nourishing reputation (PMID 26911525)..
What are other names for Donkey Hide Gelatin?
Donkey Hide Gelatin is also known as Corium. In TCM: 阿胶 (E Jiao); Colla Corii Asini.
Is Donkey Hide Gelatin safe during pregnancy?
The safety of Donkey Hide Gelatin during pregnancy has not been established. Consult a qualified healthcare provider before use.
What are the contraindications for Donkey Hide Gelatin?
Donkey Hide Gelatin should not be used in: Spleen or Stomach weakness with poor appetite, bloating, or loose stools; Thick phlegm or damp obstruction without underlying deficiency. Consult a qualified practitioner before use.