Gypsum

Chinese
石膏
Pinyin
Shi Gao
Latin
Gypsum Fibrosum
Scientific specimen plate of Gypsum, Gypsum Fibrosum, showing raw fibrous mineral pieces, powdered Shi Gao, and diagnostic material details.
Botanical plate by Kodi .

Known in TCM as Shi Gao (石膏), this sweet and acrid, very cold herb enters the Lung and Stomach. Traditionally, it clears Qi-level heat and drains fire - Shi Gao is the classic mineral for very high fever, profuse sweating, intense thirst, flushed face, and irritability when Yangming or bright excess heat is blazing, most often applied for fever, cough, and oral ulcers. Modern research has identified Calcium among its active constituents.

Part used: Gypsum

Also Known As

Fibrosum Sheng Shi Gao

Latin: Gypsum Fibrosum | Pinyin: Shi Gao | Chinese: 石膏

TCM Properties

Taste
sweet, acrid
Temperature
very cold
Channels
Lung, Stomach

Traditional Use

Primary Actions

  • Clears Qi-level heat and drains fire - Shi Gao is the classic mineral for very high fever, profuse sweating, intense thirst, flushed face, and irritability when Yangming or bright excess heat is blazing.
  • Clears Lung heat and relieves wheezing - it is used for cough, labored breathing, and thick hot sputum when the Lung is scorched by excess heat.
  • Clears Stomach fire and relieves vexing heat - traditional use extends to toothache, gum swelling, oral ulceration, raging appetite with thirst, and headache from Stomach fire.

Secondary Actions

  • Shi Gao is typically used in large crushed doses and decocted first because the mineral must be released properly to function in formulas.
  • PREPARATION NOTE: raw Shi Gao and calcined Shi Gao are not interchangeable; the calcined form is already kept in a separate repo record because its external wound-healing role is fundamentally different.

Classic Formulas

  • Bai Hu Tang - the archetypal Shi Gao formula for blazing Qi-level heat with fever, thirst, and agitation.
  • Ma Xing Shi Gan Tang - uses Shi Gao to clear Lung heat while Ma Huang and Xing Ren ventilate and descend the chest.
  • Zhu Ye Shi Gao Tang - pairs Shi Gao with fluid-restoring herbs to clear lingering post-febrile heat without ignoring depletion.

Classical References

  • TCM Wiki and classic formula commentaries consistently describe Shi Gao as sweet, acrid, and very cold, entering the Lung and Stomach to clear intense excess heat.
  • Formula traditions such as Bai Hu Tang and Yu Nu Jian show how the same mineral can target both overwhelming Qi-level fever and Stomach-fire dryness.
  • Because the herb is a mineral rather than a plant, source quality, crushing, and preparation method matter more than they do for many ordinary decoction pieces.

Modern Research

Active Compounds

  • Calcium sulfate dihydrate (CaSO4·2H2O) - the principal mineral component of raw medicinal gypsum
  • Calcium ions - likely contributors to both hydration-related and compatibility-related pharmacology
  • Sulfate and trace mineral fractions - supportive non-organic constituents discussed in quality-control work

Studied Effects

  • Earlier raw-versus-calcined research summarized in later literature found that raw gypsum retained meaningful antipyretic activity while calcined gypsum did not, supporting the classical insistence that the two preparations serve different jobs.
  • A 2013 mechanistic paper showed that Gypsum fibrosum increased aquaporin-3 expression in keratinocytes through calcium-linked PKC-ERK-CREB signaling, offering a modern explanation for hydration-supportive and dryness-relieving observations associated with the raw mineral (PMID 23912684).
  • A 2015 pharmacokinetic study found that combining Ephedrae Herba with Gypsum Fibrosum altered the plasma and urinary behavior of ephedrine alkaloids, which gives a modern rationale for classic pairings such as Ma Xing Shi Gan Tang (PMID 26087564).
  • Mineral-identification research continues because true medicinal gypsum and its processed variants need to be differentiated reliably from related powders and adulterated materials (PMID 18422183).

PubMed References

Safety & Interactions

Contraindications

  • Cold deficiency of the middle burner with loose stool and no excess heat
  • Substitution of industrial or non-medicinal gypsum products for authenticated medicinal Shi Gao
  • Use of calcined gypsum in place of raw Shi Gao for internal heat-clearing formulas

Cautions

  • Shi Gao is very cold and can burden weak digestion when given without a clear excess-heat picture.
  • The mineral is usually crushed and decocted first; incorrect preparation reduces efficacy and can create dosing confusion.
  • Raw and calcined gypsum must be sourced and used as distinct medicinals.

Conditions

Frequently Asked Questions

What is Gypsum used for?

Gypsum is traditionally used to Clears Qi-level heat and drains fire - Shi Gao is the classic mineral for very high fever, profuse sweating, intense thirst, flushed face, and irritability when Yangming or bright excess heat is blazing., Clears Lung heat and relieves wheezing - it is used for cough, labored breathing, and thick hot sputum when the Lung is scorched by excess heat., Clears Stomach fire and relieves vexing heat - traditional use extends to toothache, gum swelling, oral ulceration, raging appetite with thirst, and headache from Stomach fire.. Research has investigated its effects on: Earlier raw-versus-calcined research summarized in later literature found that raw gypsum retained meaningful antipyretic activity while calcined gypsum did not, supporting the classical insistence that the two preparations serve different jobs.; A 2013 mechanistic paper showed that Gypsum fibrosum increased aquaporin-3 expression in keratinocytes through calcium-linked PKC-ERK-CREB signaling, offering a modern explanation for hydration-supportive and dryness-relieving observations associated with the raw mineral (PMID 23912684)..

What are other names for Gypsum?

Gypsum is also known as Fibrosum, Sheng Shi Gao. In TCM: 石膏 (Shi Gao); Gypsum Fibrosum.

Is Gypsum safe during pregnancy?

The safety of Gypsum during pregnancy has not been established. Consult a qualified healthcare provider before use.

What are the contraindications for Gypsum?

Gypsum should not be used in: Cold deficiency of the middle burner with loose stool and no excess heat; Substitution of industrial or non-medicinal gypsum products for authenticated medicinal Shi Gao; Use of calcined gypsum in place of raw Shi Gao for internal heat-clearing formulas. Consult a qualified practitioner before use.